3 edition of Intracellular trafficking of proteins found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Clifford J. Steer, John A. Hanover.|
|Series||Intercellular and intracellular communication ;, 5|
|Contributions||Steer, Clifford J., Hanover, John A.|
|LC Classifications||QP551 .I59 1990|
|The Physical Object|
|Pagination||xxvi, 745 p. :|
|Number of Pages||745|
|LC Control Number||90001774|
Intracellular trafficking of viral movement proteins (MPs) in plants has mainly been studied using Tobacco mosaic virusMP30 (TMV MP30) as a model e of the limitations of TMV MP30 expression in Arabidopsis thaliana, these studies have mostly been restricted to tobacco we present data on the analysis of transgenic Arabidopsisplants expressing Potato leafroll virus To this end, we will investigate the effects of a-synuclein overproduction and consequent aggregation on the rate of intracellular trafficking by following the trafficking of transferrin receptor, a well-characterized cargo protein of the microtubule transport system.
This review will discuss the role of lysosomal membrane proteins in the biogenesis of the late endosomal and lysosomal membranes, with particular emphasis on the structural features and molecular mechanisms underlying the intracellular trafficking of these proteins. Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions Mengmeng Qin 1,2, specific proteins, the nano-trafficking routes can be clarified. Although there are a few of studies related to this issue already. Howeve[25, 26]r, the present.
The overview of intracellular trafficking pathways is shown in Figure1 (adapted from Orlando, et al, ). Studies on intracellular trafficking can be traced back show more content In particular, cargoes and v-SNARE are sorted into newly-forming buds with the assistance of cargo receptors, coat proteins and some other factors. ISBN: OCLC Number: Description: pages: illustrations ; 25 cm: Contents: Intracellular protein trafficking and proprotein processing: an overview / Harold Gainer --Intracellular trafficking of pre-(pro) proteins across RER membranes / William R. Skach and Vishwanath R. Lingappa --Protein transport from the endoplasmic reticulum to the golgi apparatus.
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Intracellular and nuclear trafficking of endogenous FGF proteins Intracellular trafficking of endogenous FGF molecules is believed to result in intracrine signaling.
This is best exemplified by the members of the FHF subfamily, which show a relatively low homology with other family members, lack leader sequences and, unlike all other FGFs, are.
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Author: Clifford J. Steer ISBN: Genre:. The intracellular trafficking of GLUT2 can be monitored by pulse-chase labeling of islet cells with [35 S]-methionine, in conjunction with sequential purifications of biotinylated cell-surface proteins and GLUT2. To prepare sufficient islet cells for pulse-chase labeling, at.
Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins RAB-5, RAB-7, and RAB, known modulators of endocytosis in all eukaryotes (Grant and Hirsh, ).
Thus yolk uptake provides a genetically tractable system for the study of clathrin and Rab dependent transport processes. RME-2 contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits.
Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins RAB-5, RAB-7, and RAB, known modulators of.
However, the details of the intracellular trafficking pathway of nanoparticles in cells have been poorly investigated. Here, we investigate in detail the intracellular trafficking pathway of protein nanocapsules using more than 30Rab proteins as markers of multiple trafficking vesicles in endocytosis, exocytosis and autophagy.
We observed that. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.
Transmembrane protein trafficking is a highly dynamic and efficient process regulated by a network of proteins. Over the past decade, AP complexes have become known as key regulators of this process.
Each AP complex performs the specific sorting function at distinct intracellular. This review summarizes findings on a new family of small cytoplasmic proteins called copper chaperones. The copper chaperones bind and deliver copper ions to intracellular compartments and insert the copper into the active sites of specific partners, copper-dependent enzymes.
Three types of copper chaperones have been found in eukaryotes. Their three-dimensional structures have been. Trafficking of GPI‐anchored proteins in CHO cells. We characterized the trafficking pathway of endocytosed folate receptors in a CHO cell line which expresses a transfected human transferrin receptor and human GPI‐anchored folate receptor (FRαTb‐1 cells; Mayor and Maxfield, ).The distribution of PLF fluorescence after binding to FRαTb‐1 cells at 0°C is also consistent with.
The regulated recycling of endocytosed membrane proteins at the plasma membrane is an important intracellular trafficking process that can regulate the copy number of proteins at the membrane and. Explore the latest full-text research PDFs, articles, conference papers, preprints and more on INTRACELLULAR TRAFFICKING.
Find methods information, sources, references or. Trafficking of secreted proteins A. McCRACKEN The T-cell antigen receptor: assembly and expression of a multisubunit complex J. BONIFACINO, J.
LIPPINCOTT-SCHWARTZ and R. KLAUSNER The polarized transport of surface proteins and lipids in epithelial cells A. WANDINGER-NESS and K. SIMONS III PROTEIN TRANSPORT INTO NUCLEI.
In this Review, the authors evaluate the strategies that the intracellular pathogenLegionella pneumophilauses to establish growth inside cells and probe why.
Intracellular transport and maturation of nascent low density lipoprotein receptor is blocked by mutation in the ras-related GTP-binding protein, rabib 26 September | Journal of Receptors and Signal Transduction, Vol. 15, No. Since the beginning of the 21 st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes.
In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. It is the only book that covers the principles of intracellular trafficking and processing of proproteins using examples representative of different classes of proproteins in the cell.
New classes of enzymes, especially proteases with unique specificities, are examined as well. Rab family proteins are specific markers on the endo trafficking vesicles, which are excellent vesicle markers to investigation the detail intracellular trafficking of the nanoparticles.
These new trafficking findings will provide new targets to interfere the cellular behaver of the nanoparticles, and improve the therapeutic effect of nanomedicine. Atg23 is a peripheral membrane protein that facilitates the anterograde trafficking of Atg9 from the Golgi to the PAS.
Atg27, another transmembrane protein that facilitates formation of Atg9 vesicles at the late Golgi, is itself observed to be present in early/late endosomes, PAS, Golgi and vacuolar membrane.
Abstract. Vesicle trafficking between intracellular compartments of eukaryotic cells is mediated by conserved protein machineries.
In each trafficking step, fusion of the vesicle with the acceptor membrane is driven by a set of distinctive soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins that assemble into tight 4-helix bundle complexes between the fusing.
The positive result of the allelic test between pat and pat confirmed that trafficking defect reflecting intracellular accumulation of proteins in pat, is caused by mutation in the gene.Annexin 11 is known to play a role in vesicular trafficking between the Golgi and endoplasmic reticulum.
Functional studies in transfected cells revealed abnormal binding of mutant annexin 11 to calcyclin, which implicates defective intracellular protein trafficking in ALS pathogenesis.ER-Golgi protein trafficking inhibitor.
Inhibition of intracellular protein trafficking by Brefeldin A. Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus .
The blocking of intracellular vesicle movement in BFA-treated cells causes the.